Introduction: According to the World Health Organization, the premature newborn with very low birth weight is a neonate that weighs less than 1,500 grams at birth. Around this group of babies there is a great debate around how they should  be fed, as they are influenced by gestational age after birth as corrected gestational age after medical discharge, the possible complications that could be a result of prematurity and the degree of malnutrition accumulated throughout their hospital stay.

Objective: To know the best evidence based there around feeding preterm neonate of very low birth weight during their hospital stay in an intensive care unit.

Methodology: In order to place the issues of the systematic literature review, the search were made on PubMed and on different websites.

Once defined the topic, the databases used were PubMed and Cochrane.

For the inclusion of items were taken into account: articles written in English or Spanish, which were clinical trials, reviews or both, published in the last 5 years, and they had relation to the target.

Participants included were preterm newborn with very low birth weight, admitted to an intensive care unit.

A total of 26 articles were found, 15 PubMed and 11 Cochrane.

Results: A feeding of breast milk reduces the incidence of one of the most common diseases in very premature neonate, necrotizing enterocolitis, being a safe practice the minimum nutrient management from the outset.